A young female patient on chronic steroid therapy developed Cytomegalovirus gastritis with suspected dissemination.With no other identifiable cause of immune suppression, diagnosis of this unlikely infection under this Adapters circumstance proved a challenge.Her non-compliance to treatment further complicated matters.This case highlights the importance of having a high degree of suspicion in diagnosing an unlikely alphapro infection in an unforeseen circumstance.It also brings to the limelight the need for clear guidelines on initiating antiviral therapy in non-transplant patients.